I saw a lady (maybe in 20s) playing a game on DS in a crowded train this morning!
I could't see the screen clearly, so i don't know which game she was playing, but at least it was not Brain Age-ish game because she never used her stylus.
I see many people playing DS games in a train. Not only little kids but also middle-aged women are playing. I also see people playing PSP in a train sometimes, but they are usually not kids or ladies but men.
It seems that Nintendo is achieving to get new fans.